ORGN 715 |
| Using a protected version of aspartic acid semi-aldehyde as a key intermediate, short efficient routes have been developed for the synthesis of a number of biologically active, non-proteinogenic amino acids. These include Gizzerosine 1 which causes the disease ‘black vomit' in poultry and amino acids with diazirine side-chains (e.g. 2), which have been used to identify protein-protein interactions in the cellular environment by UV-induced photo-crosslinking.
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Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
