Bismuth compounds in organic synthesis: Bismuth iodide catalyzed deprotection of acetals and ketals in water

ORGN 474

Ram S. Mohan, rmohan@iwu.edu, Aaron D. Bailey, and Ashvin R. Baru. Laboratory for Environmentally Friendly Organic Synthesis, Department of Chemistry, Illinois Wesleyan University, 201 East Beecher Street, Bloomington, IL 61701
An environmentally-friendly method for the deprotection of acetals and ketals catalyzed by bismuth iodide in water has been developed. Water is a very environmentally-friendly solvent due to its non-toxicity, easy availability and non-flammable nature. Bismuth compounds are attractive as catalysts in organic synthesis because of their remarkably low toxicity and ease of handling. Herein, we report the bismuth iodide catalyzed deprotection of a variety of acetals and ketals in water. The results of this study will be presented.