Enantioselective synthesis of (—)-lobeline via desymmetrization

ORGN 297

Hui Jiang, hjiang@artsci.wustl.edu, Ximin Li, xlia@artsci.wustl.edu, and Vladimir B. Birman, birman@wustl.edu. Department of Chemistry, Washington University in St. Louis, Campus Box 1134, One Brookings Drive, St. Louis, MO 63130
A concise asymmetric synthesis of (–)-lobeline via desymmetrization of lobelanidine using a nonenzymatic enantioselective acyl transfer catalyst will be described.

 

Total Synthesis of Complex Molecules
1:00 PM-4:40 PM, Monday, March 26, 2007 McCormick Place East -- Room E352, Level 3, Oral

Division of Organic Chemistry

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007