ORGN 229 |
| Catalysis often allows for increased selectivity and efficacy of chemical transformations. We have developed a number of catalytic transformations, each giving ready access to an important class of products: the Suzuki-Miyaura cross-coupling and Sonogashira coupling of sterically hindered substrates using a new class of N-heterocyclic carbene ligands (IBiox), the organocatalyzed conjugate umpolung with N-heterocyclic carbenes for the synthesis of γ-butyrolactones, the Cu-catalyzed synthesis of oxazoles and benzoxazoles by domino-C-N-/C-O-bond formation, and finally the asymmetric hydrogenation of auxiliary-substituted pyridines providing highly enantiomerically enriched piperidines. An overview on these methods will be given. |
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Herbert C. Brown Award for Creative Research in Synthetic Methods: Symposium in Honor of David A. Evans
8:30 AM-12:00 PM, Monday, March 26, 2007 McCormick Place Lakeside -- Room E450 A/B, Level 4, Oral
Division of Organic Chemistry |