ORGN 724 |
| Enantiomerically enriched pyrazolidinones have received attention as versatile chiral building blocks. Only one example for the synthesis of enantiomerically enriched pyrazolidinones via kinetic resolution of azomethine imines has been reported. However, kinetic resolution involves a significant disadvantage as half of the starting material is discarded. Herein, we wish to report a straightforward asymmetric synthesis of chiral 3-substituted-pyrazolidinones with high enantioselectivity in good yields via highly regio- and enantioselective addition of hydrazines to α,β-unsaturated imides. Details of the synthetic methodology and scope of the methodology will be presented
|
|
Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
