Asymmetric organocatalyst mediated radical reactions

ORGN 722

Masayuki Hasegawa, masayuki.hasegawa.1@ndsu.edu1, Jake Zimmerman2, and Mukund P. Sibi, Mukund.Sibi@ndsu.edu1. (1) Department of Chemistry, North Dakota State University, Fargo, ND 58105, (2) Department of Chemistry, Ohio Northern University, Ada, OH 45810
Chiral Lewis acids have played an important role in the development of enantioselective radical reactions. In the past ten years a number of radical C-C and C-H bond formations that proceed with high levels of enantioselectivity have been reported. Asymmetric synthesis mediated by organocatalysts is at the forefront of synthetic organic chemistry. However, organocatalysis has seen limited application in radical chemistry. We describe here highly enantioselective α-carbonyl oxygenations and 1,4-conjugate additions using organocatalysts. Substrate scope and approaches to tandem bond formation will also be presented.

 

Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Division of Organic Chemistry

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007