ORGN 584 |
| Homogeneous gold catalysts are particularly valuable for the activation of C-C double and triple bonds. We are particularly interested in the stereoselective synthesis of α- or β-hetero-substituted allenes and their gold-catalyzed stereocontrolled conversion (with axis-to-center chirality transfer) into target molecules of biological and pharmacological relevance. Our contributions include the first example of a gold-catalyzed C-S bond formation by converting α-thioallenes into 2,5-dihydrothiophenes. Applications of these transformations in the synthesis of heterocyclic target molecules will be also presented.
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Metal-Mediated Reactions and Syntheses
1:00 PM-4:20 PM, Wednesday, March 28, 2007 McCormick Place Lakeside -- Room E350, Level 3, Oral
Division of Organic Chemistry |
