ORGN 125 |
| Cupric chloride and bromide are found to be excellent halocyclization agents for 2-alkynylthioanisoles and 2-alkynylanilines. Thus, treatment of 2-alkynylthioanisoles with two equivalents of CuX2 (X = Cl or Br) under refluxing acetonitrile for 2-3 hours gave 3-halobenzo[c]thiophenes in good to excellent yields. On the other hand, N,N-dimethyl-2-alkynylanilines gave 3-haloindoles under similar reaction conditions.
|
|
Process R&D, Physical Organic Chemistry, Heterocycles, Aromatics, Metal-Mediated Reactions
8:00 PM-10:00 PM, Sunday, March 25, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |