ORGN 484 |
| Mechanistic investigations of tandem reactions provide vital insight into the development of new synthetic strategies. The combination of catalytic hydroamination and the Strecker reaction has led to efficient methodologies for the syntheses of many products that are laborious to access through traditional reaction sequences. Hydroamination of terminal alkynes with primary amines yields aldimines with no by-products, such as water. Therefore, these aldimines can be used without isolation in further reactions, including those that may be sensitive to water. This methodology has been used to synthesize a number of novel nitrogen-containing compounds. The mechanism of these tandem reactions has also been probed, and this insight has been applied toward the design of enantioselective versions of these methods.
|
|
New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Sci-Mix
Division of Organic Chemistry |
