ORGN 245 |
| The ability to control the structures, and therefore the properties, of surfaces has made self-assembled monolayers a central element of studies in a broad range of interfacial problems. Yet, the development of interfacial reactions is still a difficult and slow process, owing to the challenges in characterizing the products and yields of the conversions. This presentation illustrates the use of matrix-assisted laser desorption/ionization and time-of-flight mass spectrometry (MALDI-TOF MS) to characterize the interfacial reaction products. This method was used to demonstrate sixteen high yielding organic transformations of functional groups presented on self-assembled monolayers. The method has been extended to screening reaction conditions to identify unexpected conversions of common functional groups. The combination of mass spectrometry methods to identify reaction products and self-assembled monolayers to control the reaction environments provides a new opportunity to both develop and discover interfacial reactions. |
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Combinatorial and Process Chemistry
8:00 AM-11:40 AM, Monday, March 26, 2007 McCormick Place East -- Room E350, Level 3, Oral
Division of Organic Chemistry |