ORGN 597 |
| Lonomycin A, which was isolated from Streptomyces ribosidificus in 1975, is a polycyclic ether constituted of 6 highly functionalized rings and 23 stereocenters. Our synthetic strategy rely on the asymmetric Michael additions of propionate enolates to α, β unsaturated esters to introduce stereoselectively the contiguous and alternating methyl and methoxy moieties. This attractive methodology avoids the use of tedious protection-deprotection protocols and gives easily access to crucial intermediates in our synthetic approach.
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Asymmetric Reactions and Syntheses
1:00 PM-5:00 PM, Wednesday, March 28, 2007 McCormick Place Lakeside -- Room E351, Level 3, Oral
Division of Organic Chemistry |
