ORGN 401 |
| Dysiherbaine and a select number of structurally related compounds have shown to have selective effects on ionotropic glutamate receptors (iGluRs). iGluRs are essential components in the central nervous system (CNS); playing an important role in memory and learning. They also play a role in a number of neurological disorders, including schizophrenia, epilepsy, Rasmussen's encephalitis and stroke; along with neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases. This presentation describes efforts toward the total synthesis of dysiherbaine and its structural analogues. Our key intermediate (A) is a precursor of dysiherbaine and its analogues. Precursor A will provide dysiherbaine and a series of analogues without having to design a new total synthesis for each analogue. This work will provide unique molecules that will enhance the understanding of the structure and function of ionotropic Glu receptors in the CNS.
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New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Sci-Mix
Division of Organic Chemistry |
