ORGN 274 |
| There are many ways to prepare alpha amino acids. Often the “best” method depends upon the scale of production. A number of approaches used by DSM will be described. These range from the use of dynamic kinetic resolutions, so that there is no waste stream from the “wrong” isomer, to enzymatic methods where the coupling of two or more transformations also allow for both isomers of a substrate to be converted the desired isomer of the amino acid. In addition, asymmetric hydrogenation allows for a rapid method to prepare alpha amino acids, especially when the catalyst system can be found by a high-throughput experimentation protocol. |
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Asymmetric Syntheis of α-Amino Acids: Novel Developments and Future Directions
1:00 PM-5:40 PM, Monday, March 26, 2007 McCormick Place Lakeside -- Room E350, Level 3, Oral
Division of Organic Chemistry |