ORGN 236 |
| A procedure for the preparation and separation of capreomycin analogs will be presented. The protocol involves conversion of capreomycin, a mixture of 4 congeners (IA, IB, IIA, and IIB), to a mixture of arylated analogs. The mixture is then sequentially protected to enable chromatographic separation of the individual constituents. After deprotection, the desired analogs can be isolated as single components in high purity. This approach has been successfully demonstrated on kilogram scale.
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Combinatorial and Process Chemistry
8:00 AM-11:40 AM, Monday, March 26, 2007 McCormick Place East -- Room E350, Level 3, Oral
Division of Organic Chemistry |
