ORGN 72 |
| The challenge with the development and scale-up of this antibacterial candidate was the fact that the starting material is a natural product containing a mixture of four components in an approximate ratio of 45:45:5:5. The major components were differentiated by having either a serine or alanine amino acid handle. This enabled derivatisation and separation by chromatography utilizing in-line UV monitoring together with HPLC analysis and was demonstrated on scale to separate multi-kilogram quantities of this advanced intermediate. The impurity profile of the API also provided both an analytical and engineering challenge and a robust process and controlled drying process was developed to ensure reproducibly high quality product. |
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Process R&D, Physical Organic Chemistry, Heterocycles, Aromatics, Metal-Mediated Reactions
8:00 PM-10:00 PM, Sunday, March 25, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |