ORGN 134 |
| A convenient, novel synthesis of gem-dimetalloakanes containing boron and germanium based on the α-bromoalkyllboronate esters is developed. Alpha-bromoalkylboronate esters readily available from literature procedures smoothly undergo a reaction with freshly generated trimethylgermyllithium in hexamethylphosphoramide (HMPA) at -78 oC to provide the corresponding tetracoordinated boron complexes. These boron complexes undergo intramolecular nucleophilic substitution reaction to provide the corresponding alkylboronate esters containing trimethylgermyl moiety. These intermediates are isolated in good yields (72%-84%) and are characterized by the spectral data (PMR and CMR). |
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Process R&D, Physical Organic Chemistry, Heterocycles, Aromatics, Metal-Mediated Reactions
8:00 PM-10:00 PM, Sunday, March 25, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |