ORGN 412 |
| The urea cycle is comprised by five enzymes, but also requires other enzymes and mitochondrial amino acid transporters to function fully. The mechanism of carbamoyl phosphate formation, nitrogen accretion, decreased urea excretion, CLUT-1,2,3,4 role is not comletely understood. The dividing preimplantation embryo does not use glucose for fuel. It is reported that chromosomes increase in size when embryo of a mice is placed under increased concentration of glucose. In contrast to the liver cells, where glucagon, insulin and corticoids are major regulators of the urea cycle, in nonheapatic cells the urea cycle enzymes are regulated from various pro and antiinflamatory cytokins and other agents. Adenylosuccinate synthetase and adenylosuccinase do not appear to increase during S phase. Experiments reveal that urea can form small nucleotides. I used enol formation, creation of nucleophiles,condensation and rearrangement of urea, pyruvate and phosphate to propose a reliable chemical mechanism for synthesis of nucleotides, water, acetyl groups for histone deacethylase, methyl from cytosine, and generating carbamoyl phosphate entering a new cycle. It supports the theory for prebiotic nucleotide formation by using molecules synthesized in Miller's experiments. It would support the approach of epigenetics that acetylation is a substrate for histone deacetylase in order for transcribtion to occur and methylation on cytosine stops coding. It would be supporting the modern concept of predetermined replication induced by transduction signals form controling immune cells for control of arginase activity and arginine methabolism, and only a cell can stimulate a division of another cell in multicellular organisms. It could be a target for developing anicancer drugs, better understanding for viral replication, and an object for controling proliferation of stem cells.
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New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |