| MEDI | Thursday, 14 September 2006 | ||
1:30 PM-4:50 PM Moscone Center -- Room 102, Oral | |||
General Oral Session | |||
| Organizer: | David P. Rotella | ||
| 1:30 PM | 572 | Identification of azacycles as privileged ligand scaffolds for the design and synthesis of aspartic protease inhibitors Andreas Blum, Sascha Brass, Nan-Si Chan, Wibke E. Diederich | |
| 1:50 PM | 573 | Imidazo[4,5-c]quinoline-based TLR7 and TLR8 immune response modifiers: Structure-activity-relationships relating to potency, selectivity, and therapeutic applications Tushar A. Kshirsagar, George W. Griesgraber, Doris Stoermer, David T. Amos, Kyle J. Lindstrom, Michael J. Rice, Stephen L. Crooks, Jason D. Bonk, Joseph F. Dellaria, Philip D. Heppner, John F. Gerster, Bryon A. Merrill, Sarah C. Johannessen, Bernhard M. Zimmermann, Gregory Marszalek, Luke T. Dresssel, Chad A. Haraldson, David J. Squire, Joshua R. Wurst, Matthew R. Radmer, Karl J. Manske, Sarah J. Spessard, Scott E. Langer, Gregory P. Karp, Sheila J Gibson, Lindsay R. Wurst | |
| 2:10 PM | 574 | Novel heterocyclic TLR7 and TLR8 immune response modifiers: Design and synthesis of cytokine-inducing ring systems David S. Hays, Kyle J. Lindstrom, John F. Gerster, Ryan B. Prince, Michael E. Danielson, Jason D. Bonk, William H. Moser, Gregory D. Lundquist, Shri Niwas, Nick Nikolaides, Chad A. Haraldson, Bryon A. Merrill, Joshua R. Wurst, Peter V. Maye, Ganesh A. Kumar | |
| 2:30 PM | 575 | Design, synthesis, and SAR of novel benzimidazole based HDAC inhibitors Haishan Wang, Niefang Yu, Hongyan Song, Dizhong Chen, Weiping Deng, Pek Ling Lye, Yong Zou, Melvin Ng, Joyce Chang, Eric T Sun, Kanda Sangthongpitag, Xukun Wang, Xiaofeng Wu, Hwee Hoon Khng, Siok Kun Goh, Pauline Yeo, Xin Liu, Evelyn Goh, Lee Sun New, Kantharaj Ethirajulu, Michael Entzeroth | |
| 2:50 PM | 576 | Design, synthesis and evaluation of conformationally constrained bivalent Smac mimetics as inhibitors of IAP family proteins Haiying Sun, Nikolovska-Coleska Zaneta, Jianfeng Lu, Chao-Yie Yang, Su Qiu, Shaomeng Wang | |
| 3:10 PM | 577 | Design of PAP-1, a selective small molecule Kv1.3 blocker for the suppression of effector memory T cells in autoimmune diseases Ananthakrishnan Sankaranarayanan, Philippe Azam, Daniel Homerick, Heike Wulff | |
| 3:30 PM | 578 | Macrocyclic inhibitors of the caspase-9/BIR3 interaction: Structural and biochemical characterization Stephen M. Condon, Matthew G. LaPorte, Yijun Deng, Susan R. Rippin, T. Pavan Kumar, Yu-Hua C. Lee, Mukta Hendi, Jonathan Chou, Martin E. Seipel, Lichuan Gu, Stacy L. Springs, Jennifer M. Burns, Christopher A. Benetatos, Yigong Shi, Mark A. McKinlay, Srivinas K. Chunduru | |
| 3:50 PM | 579 | Novel cucurbitacin derivatives: Potential anticancer candidates Andrew J. Young, Fathi T. Halaweish | |
| 4:10 PM | 580 | Novel, orally bioavailable N-substituted imidazole-based MEK inhibitors as potential anticancer agents Andreas Goutopoulos, Amanda Sutton, Srinivasa Karra, Qihong Xu, David Fischer, Wendy Zhang, Carolyn Hum, Nadia Brugger, Brian Healey, Zhaowen Luo, Malcolm McGregor, Xuliang Jiang, Arun Ramamurthy, Robert Murray, Sharad Magar, Peter Blume-Jensen, John Zhang, Roustem Nabioullin, Tony Arulandandam, Mark Tepper, Ben Askew, Steve Arkinstall, Paolo Marinelli, Lucia Golzio, Claudio Giachetti, Matthias Schwarz | |
| 4:30 PM | 581 | Scaffold jumping in the rational design of novel HIV-1 NNRTI's Jeff O'Meara, Araz Jakalian, Steven Laplante, Pierre R. Bonneau, René Coulombe, Ingrid Guse, Christiane Yoakim, Bruno Simoneau | |
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
Symposium Grid -- Drug Discovery -- Session Listing
The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006