Session: Small Molecule Activators of Apoptosis as Anticancer Agents


MEDI		Sunday, 10 September 2006

1:30 PM-4:50 PM Moscone Center -- Room 102, Oral
Small Molecule Activators of Apoptosis as Anticancer Agents

Organizers:	Paul J. Hergenrother Chengguo Xing
1:30 PM	17	Design of bivalent Smac mimetics as highly effective and specific apoptosis inducers in cancer cells Shaomeng Wang, Haiying Sun, Jianfeng Lu, Zaneta Nikolovska-Coleska, Su Qiu, Dongguang Qin, Yuefeng Peng, Han Yi, Wei Gao, Chao-Yie Yang, Jeanne Stuckey, Jennifer Meagher, Krzysztof Krajewski, Sheng Jiang, Peter P. Roller
2:10 PM	18	Discovery of ABT-737, an inhibitor of Bcl-2 family proteins that promotes apoptosis Michael D Wendt
2:50 PM	19	Studying mechanisms of cell death: From apoptosis to necrosis Junying Yuan, Alexei Degterev, Zhihong Huang, Mike Boyce, Prakash Jagtap, Greg Cuny, Michael Moskowitz
3:30 PM	20	Synthesis and apoptotic activity of new caspase-activating pentacyclic triterpenoids Ali Koohang, Ze-Qi Xu, Aye Aye Mar, Nathan D. Majewski, David A. Eiznhamer, Erika L. Szotek, Michael T. Flavin
4:10 PM	21	A chemical genetics approach for the discovery of activators of apoptosis: From phenotypic cell based HTS assay and structure-activity relationship studies, to identification of potential anticancer agents and molecular targets Sui Xiong Cai