| ORGN | Monday, 11 September 2006 | ||
8:10 AM-12:00 PM Moscone Center -- Room 135, Oral | |||
Peptide Bond Isosteres | |||
| Organizer, Presidings: | Donna M. Huryn Peter Wipf | ||
| 8:10 AM | Introductory Remarks | ||
| 8:15 AM | 247 | Converting peptides to drugs Gregory L. Verdine | |
| 8:50 AM | 248 | From amino acids to peptide isosteres: Implications to peptide-lead drug templates for genome-lead drug discovery Nobutaka Fujii, Shinya Oishi, Tetsuo Narumi, Kenji Tomita, Hiroaki Ohno | |
| 9:25 AM | 249 | Backbone amide mutagenesis to understand the energetics of hydrogen-bonding in protein folding Jeffery W. Kelly, Evan T Powers, Songpon Deechongkit, Jan G Bieschke, Yanwen Fu, Gianmin Gao, Philip E. Dawson | |
| 10:00 AM | Intermission | ||
| 10:10 AM | 250 | Silanediols as neutral, stable hydrated carbonyl mimics for protease inhibitor design Scott McN. Sieburth, Wondwossen D. Arasho, Madhusudhan Purushotham, Sushmita Sen, Jin Kyung Kim, Richard P. Gaines | |
| 10:45 AM | 251 | Trifluoroethylamine function as peptide bond replacement Matteo Zanda | |
| 11:20 AM | 252 | Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K S Léger | |
| 11:55 AM | Concluding Remarks | ||
Symposium Grid -- Division of Organic Chemistry -- Session Listing
Symposium Grid -- Biotech -- Session Listing
Symposium Grid -- Drug Discovery -- Session Listing
The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006