Capped mesoporous silica nanoparticles for intracellular controlled release and drug delivery

COLL 51

Victor S-Y. Lin, vsylin@iastate.edu, Department of Chemistry and Ames Laboratory, Iowa State University, 0755 Gilman Hall, Iowa State University, Ames, IA 50011
We have developed a series of mesoporous silica nanosphere (MSN) materials as stimuli-responsive controlled release delivery carriers. Several pharmaceutical drugs and neurotransmitters were encapsulated inside the mesopores of MSN by capping the openings of the mesopores with various chemically removable caps to block the molecules of interest from leaching out. We studied the stimuli-responsive release profiles of several drug/neurotransmitter-loaded MSN systems by using various non-cytotoxic chemicals as release triggers. Furthermore, the gene transfection efficacy, uptake mechanism, and biocompatibility of the capped-MSN system with various cell types, such as neural glia (astrocytes), human cervical cancer (HeLa), and Chinese hamster ovarian (CHO) cells were investigated. The mesoporous structure of the MSN material allows membrane impermeable molecules, such as pharmaceutical drugs and fluorescent dyes, to be encapsulated inside the MSN channels. We envision that these MSNs can serve as a universal transmembrane carrier for intracellular drug/gene delivery and imaging applications.
 

Advances in Nanomedicine
8:30 AM-12:20 PM, Sunday, 10 September 2006 Sir Francis Drake -- Monterey/Cypress Rooms, Oral

Division of Colloid & Surface Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006