COLL 46 |
| Carbon nanotubes (CNT) are explored as novel nanomaterials for biomedical applications, which include their use as DNA biosensors, protein biosensors and transporters, ion channel blockers and drug and gene delivery systems. We have shown that water-soluble ammonium-functionalised CNT are compatible with the biological milieu and can act as delivery systems for genes transported into mammalian cells with minimal cytotoxicity. In this communication we present our data using functionalised single-walled (f-SWNT) and multi-walled (f-MWNT) carbon nanotubes as new vectors for the delivery of therapeutic molecules to cells and organs. The interaction of CNT with cells (in vitro) and organs (in vivo) indicates their capacity to be uptaken by cells and get cleared from blood circulation without undesirable side effects, illustrating the potential of such novel nanomaterials for therapeutic or diagnostic purposes. |
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Advances in Nanomedicine
8:30 AM-12:20 PM, Sunday, 10 September 2006 Sir Francis Drake -- Monterey/Cypress Rooms, Oral
Division of Colloid & Surface Chemistry |