COLL 50 |
| Recent efforts from our group to transform different types of nanomaterials as viable tools for gene delivery will be presented. The first and most exploratory nanomaterial studied is the carbon nanotube (CNT). CNT constitute a novel class of fullerene-based nanomaterials with yet unproven utilization in biomedical applications. Biomedical applications of carbon nanotubes that have been explored include delivery of genes, drugs, and antigens. The second type of nanomaterial to be presented is an adenovirus (Ad). Ad is a proteinaceous nanoparticle, even though rarely considered that way, as well as one of the most common types of viral gene therapy vector. The Ad nanoparticle has a more proven pharmacological profile than CNT, mainly from gene therapy clinical trials using Ad vectors. Ad surface engineering using different lipid molecules can lead to alterations of the nanoparticle structural characteristics which translate to modifications in the virus pharmacological and biological activity profile. |
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Advances in Nanomedicine
8:30 AM-12:20 PM, Sunday, 10 September 2006 Sir Francis Drake -- Monterey/Cypress Rooms, Oral
Division of Colloid & Surface Chemistry |