COLL 48 |
| Spherical nanoparticles are not an ideal platform for the multifunctional nanomaterials because it has a single surface so every surface modification for the multifunctionality should take place at the same surface, which can lead to malfunction or interruption between the multifunctional components. In this context, nanotube is more favorable for the development of the multifunctional nanoparticles because it has two distinctive inner and outer surfaces which can be modified differentially to have multifunctionality thanks to template synthesis. Although these differentially functionalized or multifunctionalized nanotubes have shown enormous potential in biomedical application, we cannot make use of whole volume of inner voids of nanotubes, but just the inner surface of nanotubes because the ends of nanotube are open and the leak of loaded cargo is inevitable. In this work, a strategy to seal the open ends of nanotube completely or reduce pore diameter with gold nanoparticles was exploited. Silica nanotubes and magnetic nanotubes were prepared from template “surface sol-gel” synthesis and then various sizes of gold nanoparticles were used to block the open end of those nanotubes using biointeraction or ionic interaction between inner surface of nanotube and gold nanoparticle surface. To encapsulate drug molecules and biomolecules such as DNA and protein, capping procedure was performed in the solution of those targets and their release from nanotube into the solution was investigated.
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Advances in Nanomedicine
8:30 AM-12:20 PM, Sunday, 10 September 2006 Sir Francis Drake -- Monterey/Cypress Rooms, Oral
Division of Colloid & Surface Chemistry |
