Utilizing the emerging imprint lithography technique (PRINT) for the fabrication of shape-specific organic nanoparticles for applications in nanomedicine

COLL 219

Larken E. Euliss, euliss@email.unc.edu1, Julie A. DuPont, jadupont@email.unc.edu2, Christopher M Welch3, Etta Pisano4, Weili Lin5, George W Small6, Robert Z. Orlowski, R_Orlowski@med.unc.edu6, Jonathan Serody6, Klaus M. Hahn, khahn@med.unc.edu3, and Joseph M. DeSimone, desimone@unc.edu7. (1) Department of Chemistry, University of North Carolina at Chapel Hill, B-5 Venable Hall, Chapel Hill, NC 27599, (2) Department of Chemistry, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, (3) Pharmacology, University of North Carolina, 1106 Mary Ellen Jones Building, CB# 7365, Chapel Hill, NC 27599, (4) Department of Radiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, (5) Department of Radiology, University of North Carolina, Chapel Hill, NC 27599, (6) Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, CB 7295, Mason Farm Road, 22-003 Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599-7295, (7) Departments of Chemistry and Pharmacology, University of North Carolina at Chapel Hill, Department of Chemical Engineering, North Carolina State University, CB #3290 257 Caudill Laboratories, Chapel Hill, NC 27599
The delivery of therapeutic and imaging agents for the diagnosis and treatment of cancer patients has improved dramatically with the development of polymeric nano-carriers. To date, there has been no general particle fabrication method available that has control over particle size, shape, composition, cargo and structure until now. By utilizing Particle Replication In Non-wetting Templates (PRINT) we can fabricate monodisperse particles with simultaneous control over structure and function. Unlike other particle fabrication techniques, PRINT is delicate and general enough to be compatible with a variety of therapeutics, imaging agents, cargos, targeting ligands and matrix materials. Herein, we have utilized PRINT to construct nanomaterials that contain sensing moieties. We have designed the scaffold material of the PRINT particle to contain pendant ligands that have a high affinity of the gadolinium ion. Initial phantom studies of these designer PRINT particles utilizing a MRI instrument showed an enhancement in the imaging profile.
 

Advances in Nanomedicine
1:30 PM-5:20 PM, Monday, 11 September 2006 Sir Francis Drake -- Monterey/Cypress Rooms, Oral

Division of Colloid & Surface Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006