Nitric oxide-releasing nanoparticles as anti-cancer therapeutics

COLL 107

Mark H. Schoenfisch, schoenfi@email.unc.edu1, Jae Ho Shin1, Nathan A. Stasko1, Mark A. Polizzi1, Ellen V. Stevens2, and Channing Der2. (1) Department of Chemistry, University of North Carolina at Chapel Hill, Venable Hall, CB#3290, Chapel Hill, NC 27599, (2) Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
Nitric oxide (NO), a diatomic free radical, regulates several biological functions in the cardiovascular, respiratory, immune, and nervous systems. The complex and wide ranging roles of NO in normal physiology thus demands methods for generating NO in a controlled manner. Herein, the synthesis and characterization of nanoparticles capable of storing and releasing NO are reported. The advantage of NO-releasing nanoparticles over conventional NO donor systems is the ability to store larger amounts of NO on a single molecular scaffold. In addition to the enhanced payload of NO, the size and exterior of the nanoparticle are easily modified to confer specific functionality for imaging, targeting, and/or enhanced cellular uptake. Three classes of NO-releasing nanoparticles will be discussed including monolayer-protected gold clusters, poly(propyleneimine) dendrimers, and co-condensed silica spheres. The cytotoxicity of such NO release vehicles on immortalized normal human ovarian surface epithelial and ovarian cancer cell lines will be presented.
 

Advances in Nanomedicine
2:00 PM-5:30 PM, Sunday, 10 September 2006 Sir Francis Drake -- Monterey/Cypress Rooms, Oral

Division of Colloid & Surface Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006