COLL 110 |
| Complexation of negative bilayer lipid vesicles (liposomes) with synthetic cationic polymers has been studied. The interaction was accompanied by significant structural rearrangements in the liposomal membranes: lateral segregation and transmembrane migration of lipid molecules, incorporation of adsorbed polycations into the membrane, etc. Neutralization of the liposome surface charge by adsorbed polycations favored acceleration of membrane transport of an antitumor drug doxorubicin (Dox). Anionic polymers bound electrostatically to cationic form of Dox, micro-sized polyacid-Dox complex particles being formed. Nevertheless, polymer-tied Dox molecules were able to penetrate through the liposomal membrane. When growing up polyacid/Dox ratio, the speed of Dox membrane transport decreased. An ability of synthetic polyelectrolytes to modulate membrane transport of bioactive compounds was thus demonstrated. |
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Advances in Nanomedicine
2:00 PM-5:30 PM, Sunday, 10 September 2006 Sir Francis Drake -- Monterey/Cypress Rooms, Oral
Division of Colloid & Surface Chemistry |