ORGN 361 |
| Transition metal catalysis has had a significant impact on the design of simplified methods to construct useful products. One opportunity this field provides is to begin to consider core structures as being made of multiple basic and readily available building blocks, put together all at once in one-pot catalytic processes. This talk will describe the development of such a palladium catalyzed method to prepare pyrroles from three building blocks: imines, alkynes and acid chlorides. This approach provides a method to both prepare pyrroles in one step, and to diversify their structure by simple variation of any of the three starting materials. Mechanistic studies suggest this process occurs via the formation of Münchnones. The diversity or pyrrole products available via this methodology, an alternative isocyanide mediated method to mediate this coupling, as well the use of this approach to construct other heterocyclic products in single step reactions, will be described.
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New Reactions and Methodology
8:00 AM-12:00 PM, Tuesday, 12 September 2006 Moscone Center -- Room 133, Oral
Division of Organic Chemistry |
