The azapiracids are neurotoxic marine natural products that contaminate cultured shellfish.  Their molecular architectures feature a 40-carbon backbone with a unique array of a structural moieties, including a trioxadispiroketal and an unprecedented spiroaminal fused to a 2,9-dioxabicyclo[3,3,1]nonane ring.  Total synthesis by the Nicolaou group established the complete structures of the azaspiracids.  Progress towards an alternative assembly will be summarized.  This includes highly efficient syntheses of ABCD- and EFGHI-ring containing domains, comprising C1-C20 and C20-C40, respectively.