ORGN 320 |
| A zinc carbenoid-mediated chain extension reaction is used to generate ketomethylene isosteric replacements for peptide bonds. Tandem chain extension-aldol reactions and tandem chain extension-homoenolate generation reactions are used to incorporate mimics of amino acid side chains. Identification of the stereoselectivity of the aldol reaction was established through application of a novel CAN-mediated oxidative cyclization. |
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Metal-Mediated Reactions and Syntheses
1:00 PM-5:00 PM, Monday, 11 September 2006 Moscone Center -- Room 133, Oral
Division of Organic Chemistry |