Efficient synthesis of the C1-C20 domain of azaspiracid and AZA 3- 5 analogs

ORGN 871

Son T. Nguyen, nguyen@chem.umn.edu and Craig J. Forsyth, forsyth@chem.umn.edu. Department of Chemistry, University of Minnesota, 207 Pleasant St. SE, Minneapolis, MN 55455
Among 11 azaspiracids known to date, five of them, including AZA1-5, have been isolated and characterized by NMR. In this report we disclose our efficient synthesis of the C1-C20 domain of azaspiracids, which allows access to AZA1 and AZA3-5. The convergent retrosynthetic plan for this domain is shown in scheme 1.

 

Heterocycles and Aromatics
8:00 AM-12:00 PM, Thursday, 14 September 2006 Moscone Center -- Room 135, Oral

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006