Dynamic kinetic resolution of substituted 1-phenylallyl acetates using immobilized lipases and immobilized palladium complexes

ORGN 156

Vikalp A. Thakor, kadnikovae@umkc.edu and Ekaterina N. Kadnikova, kadnikovae@umkc.edu. Department of Chemistry, University of Missouri - Kansas City, 5100 Rockhill Rd, Kansas City, MO 64110
Dynamic kinetic resolution (DKR) is evolving as an effective technique for synthesizing enantiomerically-enriched products in high yields from racemic substrates. We have used immobilized lipases and immobilized palladium complexes in DKR of substituted 1-phenylallyl acetates. We have obtained the corresponding allylic alcohols in high yields and high enantioselectivities.