ORGN 432 |
| We have synthesized a variety of aminomethanesulfonate compounds that are analogous to existing Good buffers – but with a single carbon between amino and sulfonate functionalities. These new buffer compounds present options for biological buffering in more acidic pH ranges. The compounds are synthesized in aqueous solution by reaction of primary or secondary amines with formaldehyde/sodium bisulfite addition compound. Several of the compounds tested to date show potential utility for buffering at acidic pH levels with pKa's in the range of 3 to 5 (and no solubility problems). Biological testing will be presented describing their utility as new biological buffer compounds.
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Process R&D and Practical Syntheses of Medicinal Agents
1:00 PM-4:40 PM, Tuesday, 12 September 2006 Moscone Center -- Room 132, Oral
Division of Organic Chemistry |
