ORGN 920 |
| Recent synthetic efforts towards fostriecin are presented. A tripodal coupling/multivalent activation strategy is utilized to assemble the key bicyclic phosphate, followed by selective reaction and cleavage methods to elaborate the highly functionalized natural product. The proposed pathway allows for myriad modifications and variations en route to fostriecin analogue library development. Overall, the phosphate moiety serves a multi-faceted role as a tether, multivalent activator, leaving group, and protecting group.
|
|
Total Synthesis of Complex Molecules
1:00 PM-5:00 PM, Thursday, 14 September 2006 Moscone Center -- Room 134, Oral
Division of Organic Chemistry |
