ORGN 929 |
| One-pot synthesis of β-enaminoketoesters from Weinreb amides has been developed. The reaction proceeds through tandem acyl substitution-conjugate addition by initial attack from the sodium acetylide of ethyl propynoate on a Weinreb amide. The versatility of the reaction was established by array synthesis of β-enaminoketoesters and their use as 1,3-dielectrophiles in cyclocondensation reactions. Regioselective synthesis of heterocyclic structures such as pyrazoles will be presented.
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Heterocycles and Aromatics
1:00 PM-4:40 PM, Thursday, 14 September 2006 Moscone Center -- Room 135, Oral
Division of Organic Chemistry |
