ORGN 771 |
| We describe the synthesis and characterization of water-soluble peptoid oligomers incorporating N-(S)-methoxypropyl-glycine monomer units. Peptoid sequences of varying chain length were subjected to elevated temperatures and the structural consequences were evaluated by circular dichroism spectroscopy. Our findings indicate that the polyproline I-type helical structure can be essentially abolished by thermal denaturation. Interestingly, the reversible unfolding process was observed to be highly cooperative in longer oligomers (>13mers), but not at shorter chain lengths.
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Total Synthesis, Materials, Molecular Recognition, Process R&D, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster
Division of Organic Chemistry |
