ORGN 209 |
| An effective catalytic methodology for aziridination by reactions of methyl aryldiazoacetates with selected N-aryl benzaldimines catalyzed by rhodium acetate is presented. Reactions were performed in refluxing dichloromethane using only a 10% molar excess of imine. Product yields ranged from 53 – 82%. Aziridination is stereospecific, dependent on the stability of the intermediate azomethine ylide, and in all cases only the E isomer is observed.
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Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |
