Metallocene-pyrrolidinopyridine nucleophilic catalysts for asymmetric synthesis

ORGN 151

Huy V. Nguyen, huycuong_22@hotmail.com and Christopher J. Richards, c.j.richards@qmul.ac.uk. School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London, United Kingdom
Chiral 4-aminopyridine nucleophilic catalysts 1 and 2 were synthesized in three steps starting from commercially available (S,S)-hexane-2,5-diol. The application of 1 and 2 to asymmetric catalysis will be discussed, chemistry exemplified by the Steglich rearrangement of 3 into 4.

 

Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006