ORGN 633 |
| A variety of heterocyclic sodium silanolates prepared by stoichiometric deprotonation undergo palladium-catalyzed cross-coupling with substituted aryl iodides and bromides. Silanolates prepared from indole, pyrrole, furan and thiophene are stable, easily handled reagents for cross-coupling. Key variables that led to successful cross-coupling include solvent, catalyst, and additive. The substituted heterocyclic products are obtained in good yields under mild conditions.
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New Reactions and Methodology
8:00 AM-12:00 PM, Wednesday, 13 September 2006 Moscone Center -- Room 133, Oral
Division of Organic Chemistry |
