Nickel-catalyzed asymmetric Negishi cross-couplings of secondary allylic halides

ORGN 256

Sunghee Son, sunghee@mit.edu and Gregory C. Fu, gcf@mit.edu. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139
Studies on nickel-catalyzed enantioselective Negishi cross-coupling reactions of secondary allylic halides will be presented. Preliminary results show promising regioselectivity and enantioselectivity along with functional group compatibility. The scope of the reaction will be discussd.

 

Asymmetric Reactions and Syntheses
8:00 AM-11:40 AM, Monday, 11 September 2006 Moscone Center -- Room 131, Oral

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006