ORGN 917 |
| The enantioselective synthesis of antigen Bacillus anthracis tetrasaccharide is developed in 22 steps starting from achiral acylfuran. This route relies upon an Achmatowicz rearrangement, a diastereoselective palladium-catalyzed glycosylation, Luche reductionn, and a dihydroxylation reaction. The asymmetry of tetrasaccharide is introduced by Noyori reduction of an acylfuran. Our current synthetic effort toward the tetrasaccharide will be presented.
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Total Synthesis of Complex Molecules
1:00 PM-5:00 PM, Thursday, 14 September 2006 Moscone Center -- Room 134, Oral
Division of Organic Chemistry |
