ORGN 229 |
| We are developing schemes whereby combinatorial synthesis constitutes fluorosensor array fabrication. We have demonstrated efficient combinatorial synthesis on a linear solid support. In collaboration with the Geissinger group, we have shown rapid probing of fluorosensors along an optical fiber, with individual sensor output distinguished by optical time of flight. We have prepared the Meldal SPOCC polymer as thin films covalently attached to fibers. This gel matrix is sufficiently stable for many chemical reactions, has appropriate swelling for sensor presentation in organic and aqueous solvent, and good optical properties as a fiber cladding. Our preliminary fluorosensor films respond to pH and solvent polarity. We describe here synthesis of more complex structures, and multiple linkage schemes that allow removal of a known fraction of the product for assay, leaving sensor capability intact. Noncovalent binding of these tethered substances will also be discussed. |
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Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |