ORGN 748 |
| Symbioimine 1, isolated by Uemura in 2004 from a cultured symbiotic marine dinoflagellate Symbiodinium sp., has received considerable attention as a potential target for the treatment of osteoporosis by inhibiting the differentiation of RAW264 cells into osteoclasts. These biological properties coupled with its unusual tricyclic iminium architecture has prompted interest from several synthetic groups in its biosynthesis via an intramolecular Diels-Alder (IMDA) reaction. Herein, we present our current efforts based on a flexible, convergent strategy enabling access to the advanced intermediate 3.
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Total Synthesis, Materials, Molecular Recognition, Process R&D, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster
Division of Organic Chemistry |
