Efficient and highly enantioselective reduction of oxime ethers with borane catalyzed by chiral spiroborates

ORGN 120

Xiaogen Huang, xiaogen@hotmail.com, Viatcheslav Stepanenko, and Margarita Ortiz-Marciales. Department of Chemistry, University of Puerto Rico, Humacao, UPRH, CUH station, Humacao, PR 00791
The asymmetric reduction of oxime ethers 1 with borane catalyzed by chiral spiroborates 3 derived from 1, 2-amino alcohols has been studied. Application of catalyst 3 affords optically active primary amine 2 with high yield and enantioselectivity up to 99%.

 

Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Sci-Mix

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006