ORGN 635 |
Monomeric diisopropylaminoborane (H2BN(iPr)2) promotes the reduction of a variety of nitriles to their corresponding primary amines in good yields and purity. Diisopropylaminoborane was generated in situ from lithium diisopropylaminoborohydride (LiH3BN(iPr)2) and methyl iodide. It should be pointed out that lithium diisopropylaminoborohydride itself does not reduce nitriles at room temperature.
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New Reactions and Methodology
8:00 AM-12:00 PM, Wednesday, 13 September 2006 Moscone Center -- Room 133, Oral
Division of Organic Chemistry |