ORGN 207 |
| The addition of an N-H bond across an olefin (hydroamination) is a powerful method to form nitrogen-carbon bonds. A mild, functional group tolerant method for the intramolecular hydroamination of unactivated alkenes will be reported. The tridentate ligand on palladium catalyst 1 inhibits β-hydride elimination leading to the desired transformation. The reaction can be performed at room temperature allowing the formation of five- and six-membered rings. These products contain synthetically useful nitrogen protecting groups and additional functional groups within the ring backbone.
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Asymmetric Reactions and Syntheses, Metal-Mediated Reactions, Combinatorial, Parallel, and Solid-Phase Chemistry
8:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |
