ORGN 473 |
| Bound reagents are functional polymers designed to perform synthetic transformations in same way as their solution counterparts. In this technique excess reagent and by-products remain attached to the solid, while product is in solution. Possible advantages of this technique are facile monitoring of reaction progress while reducing purification bottleneck. The disadvantage of this technique is the relative slow rate of reaction. Microwave irradiation has been used to overcome this problem and increase rate of reaction of solid-assisted solution phase synthesis. This presentation covers few examples of this technique in developing efficient and robust methods for the preparation of biologically interesting compounds, by using microwave heating in conjunction with PS-carbodiimide, PS-Ph3Pd, PS-DIEA, Si-Carbonate, Si-Thiol, and Si-triamine. |
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New Reactions and Methodology, Heterocycles and Aromatics, Bioorganic Chemistry
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Division of Organic Chemistry |