ORGN 669 |
| Peroxynitrite, a reactive nitrogen species (RNS) produced by oxidative stress, is believed to react with unsaturated fatty acids to produce nitrated lipids in vivo. Nitrated lipids contain a highly reactive nitroalkene functional group. Recent studies have shown that nitrated lipids exhibit several biological activities including protein modification, nitric oxide formation and the regulation of protein activities. We describe efficient, scalable regiospecific and stereoselective syntheses of representative nitrated lipids. We also present data from resulting biochemical investigations of nitrated lipids.
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Lipids, Nucleotides, and Mimetics
1:00 PM-4:40 PM, Wednesday, 13 September 2006 Moscone Center -- Room 131, Oral
Division of Organic Chemistry |
