ORGN 257 |
| The synthesis of organofluorine compounds is a rapidly developing area in organic chemistry due to the increasing number of biologically active compounds and their medicinal applications. The electrophilic fluorodesilylation of vinyl-, allenylmethyl- and allylsilanes has been shown to be an efficient methodology for the preparation of a variety of structurally diverse fluorinated compounds. We have initiated a research programme to investigate the diastereoselectivity and chirality transfer for the electrophilic fluorodesilylation of a range of acyclic homochiral allylsilanes. This versatile methodology has allowed for the preparation of a variety of enantiopure fluorinated building blocks. We have further exploited these diastereoselective fluorination reactions and have prepared advanced precursors of fluorinated analogues of Indinavir (a HIV protease inhibitor) and Sphingolipids
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Asymmetric Reactions and Syntheses
8:00 AM-11:40 AM, Monday, 11 September 2006 Moscone Center -- Room 131, Oral
Division of Organic Chemistry |
