ORGN 560 |
| N-Acyl oxazolidines derived from L-threonine were subjected to diastereoselective Dieckmann cyclisation and intramolecular aldol reactions to give highly functionalised tetramic acid derivatives and α-substituted pyroglutamates respectively in good yield. The products were then deprotected under Corey's conditions to give hydroxymethyl tetramic acids and hydroxymethyl pyroglutamates in high yield. The biological activity of these compounds was evaluated against S. aureus, E. coli and B. subtilis.
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New Reactions and Methodology, Heterocycles and Aromatics, Bioorganic Chemistry
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |
